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The statewide Texas Youth Depression and Suicide Research Network (TX-YDSRN) was created as a part of the Texas Child Mental Health Care Consortium (TCMHCC) to establish a state-wide research network, focused on youth depression and suicide, across all 12 Health Related Academic Institutions in Texas.


Each institution represents a TX-YDSRN Study Node within the network. UT Southwestern Medical Center serves as the TX-YDSRN Hub, under the leadership of the Scientific Lead, Madhukar H. Trivedi, M.D., and Medical Co-Lead, Sarah Mallard Wakefield, M.D., of Texas Tech University Health Sciences Center.


Create the TX-YDSRN Network

To create the Texas Youth Depression and Suicide Research Network (TX-YDSRN), developing collaborative partnerships between the 12 major medical centers throughout the state (12 “Nodes”) and building the infrastructure to support the high quality research inquiries, regulatory, operations, and research functions (UT Southwestern “Hub”)

Train Research Staff

To train research staff across the state in a standardized, best-practice model

Develop Participant Registry

To develop the TX-YDSRN Participant Registry

Collect Information

To collect information to characterize the current systems of care and intervention approaches for depressed and suicidal youth, to examine statewide population health

Overall Potential Impact and Benefit of the TX-YDSRN Research Efforts to the People of Texas

The TX-YDSRN and associated TX-YDSRN Participant Registry will impact Texas youth and families in several ways

Overall Tabs

Improve Early Detection and Evidence-Based Treatment


Many Texas communities lack the education, resources, and infrastructure needed for early detection and evidence-based treatment for youth with depression and/or suicidal thinking or behavior.


The TX-YDSRN Hub and Study Nodes provide training and support to partnering clinical sites in methods to implement evidence-based depression and suicide prevention care for youth, including universal screening for depression, use of the collaborative care model, and use of measurement-based care (MBC)


This will improve patient outcomes, save money, and reduce stigma related to mental health.

Support Clinicians in Identification and Treatment


Many pediatric providers are hesitant to treat mental health concerns, leading to inconsistent identification and treatment of depression.


The TX-YDSRN Hub team, in collaboration with Study Node leadership, offers educational and consultation opportunities for partnering clinics. In addition, clinic-level data will be provided in reports and dashboards to partnering clinics.


These trainings and collaborations lead to enhanced engagement and provide real-time feedback to improve identification and treatment processes to address youth depression and suicide prevention.

Conduct Science to Better Understand Youth Depression and Suicide


Substantial gaps exist in knowledge related to clinical, functional, behavioral, social, and biological mechanisms of depressive disorders and suicide as related to an individual’s risk of developing depression, risk of developing suicidal thoughts or engaging in suicidal behaviors, ability to cultivate resilience, and response to treatments.


Data from the TX-YDSRN Participant Registry will allow for the identification of risk markers, indicators of onset, long-term (natural) course of disease, and treatment-associated outcomes for youth depression and suicidal ideation and behavior.


Results from this study will lead to improvements in early and accurate response to depressive symptoms and suicidal ideation and behavior in youth.

Enhance Opportunities for Texas Researchers


Large grant opportunities are highly competitive and are often awarded to those with significant past proven research experience, to those with significant pilot data, or to those with access to a large population so that the results might provide more generalized data to be utilized across the nation.


Leverage expertise and experience of the TX-YDSRN Hub and Study Node leadership and combined population across participating sites.


By merging high level research expertise and mentorship for junior researchers, Texas researchers are better situated for obtaining future grant funding and results will be more generalized.

Sustain a Texas Research Infrastructure to Address Youth Depression and Suicide Prevention


While Texas has several large research institutions, many of the Academic Health-Related Institutions across the state are focused primarily on clinical care and do not have significant research infrastructure.


Establishing The TX-YDSRN, comprised of the Academic Health-Related Institutions across the state, leveraged the infrastructure and expertise of larger Health-Related Institutions to support smaller Health-Related Institutions. Each Study Node received significant training and will continue to receive support and maintenance training from the TX-YDSRN Hub to ensure high fidelity to research methods.


Establishing the TX-YDSRN across a state as varied as Texas will allow for investigation of a more diverse population and provide specific information that can be applied more accurately for each region. Future efforts to support our Texas youth and families will be enriched by leveraging the cultural and economic diversity of our state.


How the TX-YDSRN Research Addresses Needs in Texas

Depression and suicide impact a significant number of Texas youth. TX-YDSRN supports research to better understand depression and suicide and to improve detection and treatment through measurement-based care.

TX-YDSRN Research Infrastructure


The first step in creating TX-YDSRN was to establish the infrastructure, which included building relationships between Hub & Study Nodes, developing communication strategies, & fostering collaboration in the development and implementation of the research projects.

The TX-YDSRN Hub leads weekly Study Node coordinator meetings, bi-monthly Assessor Consultation meetings, and monthly Hub and Node Leadership meetings. Additional support includes weekly office hours for Electronic Data Capture Assistance and 1:1 meetings between the Hub and Study Nodes.


This website includes a Secure Portal Log-in where Study Nodes and affiliated clinicians can access additional information, including dashboards to support measurement-based care efforts.

Data Management:

The Electronic Data Capture (EDC) system was developed exclusively for TX-YDSRN.

Study personnel are provided access to multiple data capture sites, including the Training Tracker, with information about onboarding and training for all TX-YDSRN research personnel, the Certification Environment, which is a mock version of the data management system where research personnel can create mock participants to familiarize themselves with the EDC system, and the Production Environment, where data collection is conducted for TX-YDSRN research projects. This is only accessible to research personnel have completed all training requirements and are approved by the Institutional Review Board as personnel for the corresponding research study.

Regulatory Management

To streamline regulatory activities for TX-YDSRN, the UT Southwestern Institutional Review Board was used as the single IRB of record. The TX-YDSRN Hub worked closely with the Study Nodes to establish best practice regulatory and compliance processes.


Assessors across Texas have been trained and certified in conducting standardized research assessments to collect data on psychiatric diagnoses, depression, suicide, and trauma. TX-YDSRN research staff have been trained and certified in research methodologies and data collection and management.

TX-YDSRN Participant Registry Study


Develop the TX-YDSRN Participant Registry to collect data to characterize a sample of youth with depression and/or suicidal ideation or behavior to build predictive models for treatment outcomes trajectories of disease course and treatment selection to benefit youth with depression and/or suicidal ideation or behavior. 


Youth patients of participating TX-YDSRN clinics (ages 8-20) and their parents are being recruited for participation in the TX-YDSRN Participant Registry Study.

Upon informed consent/assent, baseline data is collected regarding mood symptoms, suicidal ideation and behavior, associated comorbidities, treatment history, services use, and social determinants of health. Youth participants and parents are sent monthly measures. Additionally, measures are given at provider visits to support delivery of measurement-based care within the clinics.

Measurement-Based and Collaborative Care Research


Clinicians across Texas have been trained in measurement-based care (MBC) and collaborative care (CC) strategies for addressing youth depression and suicide, with ongoing monthly educational opportunities and consultation offered to support MBC and CC efforts and research throughout the state.


The Measurement-Based and Collaborative Care Form (MBC/CC Form) was developed to collect information to characterize the current systems of care and intervention approaches for depressed and suicidal youth.
Future Research

Pilot Data

TX-YDSRN members have access to TX-YDSRN data to serve as pilot data for future grant applications.

Grant Submissions

The TX-YDSRN can support research projects that advance research across Texas and with the vast and varied diverse populations in Texas.